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"A ciência será sempre uma busca, jamais uma descoberta. É uma viagem, nunca uma chegada."

Karl Popper-

Publicações Selecionadas

 
DNA copy number profiles and systems biology connect chromatin remodeling and DNA repair in high-risk neuroblastoma. Genetics and Molecular Biology, 2024. DOI: 10.1590/1678-4685-GMB-2024-0007


Vitamin D and Breast Cancer Risk: Evaluating the Association and Effective Risk Reduction. Breast Care, 2024. DOI: 10.1159/000539750



Exploring snakebite epidemiology between 2010 and 2021 in Paraná, Brazil: introducing distribution patterns, clinical profiles, and sociodemographic factors. Semina, 2024. DOI: 10.5433/1679-0367.2024v45n2p197
 
A three-sequence dynamic contrast enhanced abbreviated MRI protocol to evaluate response to breast cancer neoadjuvant chemotherapy. Magnetic Resonance Imaging, 2023.


 Evaluation of the antitumoral effects of the mesoionic compound MI-D: Implications for endothelial cells viability and angiogenesis inhibition. Chemico-Biological Interactions, 2023.


A remote, fully oriented personalized program of physical exercise for women in follow-up after breast cancer treatment improves body composition and physical fitness. Sports Medicine and Health Science, 2023.
 
Evidence that BJcuL, a C-type lectin from Bothrops jararacussu venom, influences deubiquitinase activity, resulting in the accumulation of anti-apoptotic proteins in two colorectal cancer cell lines. International Journal Of Biological Macromolecules, 2022

Systems biology network reveals the correlation between COX-2 expression and Ch 7q copy number alterations in Ch 11q-deleted pediatric neuroblastoma tumors. Genes and Cancer, 2022
 

Evidence that BJcuL, a C-type lectin from Bothrops jararacussu venom, influences deubiquitinase activity, resulting in the accumulation of anti-apoptotic proteins in two colorectal cancer cell lines. International Journal of Biological Macromolecules, 2022
 
 
An overview of neuroblastoma cell lineage phenotypes and models. Experimental Biology and Medicine, 2020.
 

 ​Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP.  Cells, 2020.


 Neutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro. Journal of Venomous Animals and Toxins Including Tropical Diseases, 2020. 
 
Antiproliferative and antiangiogenic effect of Amblyomma sculptum (Acari: Ixodidae) crude saliva in endothelial cells in vitro. Biomedicine & Pharmacotherapy, 2019. 
 

Antitumoral effects of Amblyomma sculptum Berlese saliva in neuroblastoma cell lines involve cytoskeletal deconstruction and cell cycle arrest. Revista Brasileira de Parasitologia Veterinária, 2019. 
 

 Patterns of copy number alterations in primary breast tumors of South African patients and their impact on functional cellular pathways. International Journal of Oncology, 2018.
 
 

Bjcul, A snake venom lectin, modulates monocyte-derived macrophages To A pro-Inflammatory profile In Vitro. Toxicology in Vitro, 2016. 


 BJcuL, a lectin purified from Bothrops jararacussu venom, induces apoptosis in human gastric carcinoma cells accompanied by inhibition of cell adhesion and actin cytoskeleton disassembly. Toxicon, 2012. 



 
Human neutrophil migration and activation by BJcuL, a galactose binding lectin purified from Bothrops jararacussu venom. BMC Immunology, 2011.
 

 
The lectin BJcuL induces apoptosis through TRAIL expression, caspase cascade activation and mitochondrial membrane permeability in a human colon adenocarcinoma cell line. Toxicon, 2014


Intradermal injection of Bothrops cotiara venom in mice in an experimental wound model.  Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
 

A C-type lectin from Bothrops jararacussu venom can adhere to extracellular matrix proteins and induce the rolling of leukocytes. Journal of Venomous Animals and Toxins including Tropical Diseases 2007.

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